Brigitte Vannier

Associate Professor Cell Biology University of Poitiers

Habilitation 2006
University of Poitiers
Structure-activity relationship of signaling molecules: FSHR, TRP channels and PDE6 gamma examples

Post-doctoral training 1996-1999
University of California, Los Angeles
Laboratory of Pr Lutz Birnbaumer
On the molecular basis and regulation of cellular capacitative calcium entry (CCE): roles of Trp protein

PhD 1995
Biochemistry and molecular biology (Paris XI)
Laboratory of Pr Edwin Milgrom (Hôpital du Kremlin-Bicêtre)
Immunochemical and immunocytochemical characterization of the human FSH receptor. Biochemistry

Master 1991. Endocrinology (Paris XI). Universite Paris Sud Orsay

Bachelor 1990. Biochemistry (Paris VI). Universite Pierre et Marie Curie


Amakran A., Bakrim N., Vannier B., Greche H., Nhiri M. Anti-glycation and radical scavenging activities of hydro-alcohol and aqueous extracts of nine species from Lamiaceae family. B Ramdan, J. Med. Plants. Stud. 5 (1), 331-345. 2017

Sabaouni I., Vannier ·B., Moussa A.  Ibrahimi A. Hypothesis Microarray Integrated Analysis of a Gene Network for the CD36 Myocardial Phenotype. Bioinformation 12(6):322. 2016

Moussa A., Vannier B., Yennamalli R.M., Singh T.R. Recent Trends and Developments in Bioinformatics: Challenges and Opportunities. CSI Communications 40(7):28-31. 2016

Henni K., Alata O., Al Idrissi A., Vannier B., Zaoui L., Moussa A. ClusterMPP: An Unsupervised Density-based Clustering Algorithm via Marked Point Process. Intelligent Data analysis. 21 (4). 2017

El Maassarani M., · Barbarin A., · Fromont G., · Kaissi O., · Lebbe M., · Vannier B., · Moussa A., · Séité P. Integrated and functional genomics analysis validates the relevance of the nuclear variant ErbB380kDa in prostate cancer progression. · PLoS ONE. 11(5). doi: 10.1371/journal.pone.0155950. 2016

Dianzitoukoulou Matsiuma L.D., Muller J-M., Gombert J, Ouamba J-M, Seite P., Vannier B. Cytotoxicity and Mode of Action of Klainedoxa Gabonensis Pierre on U87 Gliobastoma Cancer Cell Line. Journal of Medicinal Plants Studies. 4(4).169-173.2016

Ramdan B, Ramdan R, Amakran A, Vannier B, Nhiri M. In vitro study of anti-glycation and radical scavenging activities of the essential oils of three plants from Morocco: Origanum compactum, Rosmarinus officinalis and Pelargonium asperum. Pharmacognosy Journal. 7, 124-135. 2016

O Kaissi, E Nimpaye, TR Singh, B Vannier, A Ibrahimi, A Ghacham, Ahmed Moussa. Gene Selection Comparative Study in Microarray Data Analysis. Bioinformation 01/2014; 9(20).

Sabaouni I, Moussa A., Vannier B., Semlali O., Pietka T.A., Abumrad N.A. & Ibrahimi A..The Whole Genome Expression Analysis using Two Microarray Technologies to Identify Gene Networks That Mediate the Myocardial Phenotype of CD36 Deficiency. Bioinformation. 2013. 9(17) : 849-852

Payet L.A, Pineau L, Snyder ECR, Colas J, Moussa A., Vannier B, Bigay F., Clarhaut F., Becq F., Berjeaud B., Vandebrouck C., Ferreira T. Saturated fatty acids alter the late secretory pathway by modulating membrane properties. Traffic . 09/2013

Moussa, B. Vannier & M.Maouene. New Algorithm for Gene Selection in Microarray Data Analysis Workflow. Computer Technology and Application Journal, 3 (2),169-174, 2012

Andrique L., Fauvin D., El Maasarani M., Vannier B., Seite P. ErbB380kDa, a nuclear variant of the ErbB3 receptor, binds to the Cyclin D1 promoter to activate cell proliferation but is negatively controlled by p14ARF. Cell Signal. 2012 24(5), 1074-85

Houdart F., Girard-Naud N., Morin F., Voisin P. and Vannier B. The regulatory subunit of PDE6 interacts with pacsin in photoreceptors. Mol Vis. (2005), 9, 1061-70.

Vannier B, Morin F, Houdart F, Berges T, Regnacq M and Voisin P. A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins. Mol. Vis. (2003), 18, 449-59.

Meduri G, Charnaux N, Driancourt MA, Combettes L, Granet P, Vannier B, Loosfelt H, Milgrom E. Follicle-stimulating hormone receptors in oocytes? J Clin Endocrinol Metab (2002), 2266-76.

Hai MV, De Roux N, Ghinea N, Beau I, Loosfelt H, Vannier B, Meduri G, Misrahi M, Milgrom E. Gonadotropin receptors. Ann Endocrinol (Paris). (1999), 60, 89-92.

Vannier, B, Peyton M., Zhu M., Qin N. and Birnbaumer L. Mouse trp2, the orthologue of the human pseudogene Trpc2, encodes mTrp2, a capacitative Ca2+ entry channel subunit activated by store depletion. Proc. Natl. Acad. Sci. USA. (1999). 96, 2060-2064.

Beau I, Groyer-Picard MT, Le Bivic A, Vannier B, Loosfelt H, Milgrom E, Misrahi M. The basolateral localization signal of the follicle-stimulating hormone receptor. (1998) J Biol Chem 273.18610-18616.

Vannier B, Zhu X, Brown D, and Birnbaumer L. The membrane topology of hTrp3 as inferred by glycosylation scanning mutagenesis and epitope immunocytochemistry.(1998). J. Biol. Chem., 273, 8675-8679.

Milgrom E, de Roux N, Ghinea N, Beau I, Loosfelt H, Vannier B, Savouret JF, and Misrahi M. Gonadotrophin and thyrotrophin receptors. (1997). Horm. Res. 48, 33-37.

Beau I, Misrahi M, Gross B, Vannier B, Loosfelt H, Vu Hai M, Pichon C, and Milgrom E. Basolateral localization and transcytosis of gonadotropin and thyrotropin receptors expressed in Madin-Darby canine kidney cells. J. Biol. Chem., (1997), 272, 5241-5248.

Birnbaumer, L., Zhu, X., Jiang, M., Boulay, G., Peyton, M., Vannier, B., Brown, D., Platano, D., Sadeghi, H, Stefani, E., and Birnbaumer, M.. On the molecular basis and regulation of cellular capacitative calcium entry (CCE): roles of Trp protein . (1996). Proc. Natl. Ac. Sci.USA. 93, 15195-15202.

Vannier, B, Loosfelt, H, Meduri, G, Pichon, C, and Milgrom, E. Monoclonal antibodies anti-hFSHR : Immunochemical and immunocytochemical characterization of the human FSH receptor. Biochemistry (1996), 35, 1358-1366.

Loosfelt H.,Pichon C, Jolivet A, Misrahi M, Jamous M, Vannier B, Milgrom E. Two sub-units structure of the TSH receptor. Proc. Natl. Acad.Sci. U.S.A. (1992). 89, 3765-3769.


Ouafae Kaissi, Ahmed Moussa, Brigitte Vannier, Abdellatif Amrani Ghacham: Choice Impact of Soft Analysis Tools in Genes Selection. 185-191. IWBBIO (International Work-Conference on Bioinformatics and Biomedical Engineering) March 18-20th 2013. Granada Spain.

O. Kaissi, A. Moussa, B. Vannier, and A. Ghacham. Comparative Analysis between Soft and Tools in Microarray Data Processing Proceeding of Biomedical Engineering, DOI: 10.2316/P.2013.791-086

A.Moussa, M. Maouene, and B.Vannier. Gene Selection Using the Multidimensional False Discovery Rate and the Power of Replicates . Proceeding of Biocomp2011, Las Vegas, USA, 18-22 July 2011

Moussa A., Maouene M. and Vannier B. “Multidimensional Method For Gene Selection” Proceedings of the 5th World Congress on Cellular and Molecular Biology, Indore. November 2009.


Vannier B and Moussa A. Applications of microarray technology in Gene expression analysis. Nanotechnology in health care. Shyam Prakashan Editions. April 2010.


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